The study enrolled 299 client-owned dogs with atopic dermatitis. Apoquel is dedicated to restoring quality of life by providing both short- and long-term relief of allergy-related itching for dogs. Additional clinical observations were primarily related to the interdigital furunculosis and included dermatitis (local alopecia, erythema, abrasions, scabbing/crusts, and edema of feet) and lymphadenopathy of peripheral nodes. APOQUEL is a registered trade mark of Zoetis Inc. or its subsidiaries. Over $35. One dog developed a low grade oral spindle cell sarcoma after 320 days of APOQUEL administration. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for Apoquel. Veterinarians used a 10 cm VAS scale to assess each dog’s dermatitis. In a masked field study to assess the effectiveness and safety of oclacitinib for the control of atopic dermatitis in dogs, 152 dogs treated with APOQUEL and 147 dogs treated with placebo (vehicle control) were evaluated for safety. For convenience, the dosing tables below may be used as a guideline. Dosing/Administration: The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. Apoquel Dosage. Cytopoint™ is available in 1-mL vials in four concentrations (10, 20, 30 or 40 mg). The majority of dogs in the placebo group withdrew from the 112-day study by Day 16. Walmart.com. The dog showed an elevated white blood cell (WBC) count. Avoid giving the medic… To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Zoetis Inc. at 1-888-963-8471 or www.zoetis.com. Refer to our dosage chart below. For maintenance therapy, the same dose (0.4 to 0.6 mg oclacitinib/kg bodyweight) should then be administered only once a day. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae. A double-masked, 30-day, controlled study was conducted at 26 U.S. veterinary hospitals. Dosage and Administration:The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. One dog developed low grade B-cell lymphoma after 392 days of APOQUEL administration. Always provide “Information for Dog Owners” Sheet with prescription.Use the lowest effective dose for the shortest duration consistent with individual response. Dogs in the APOQUEL group had a slight decrease in mean white blood cell counts (neutrophil, eosinophil, and monocyte counts) that remained within the normal reference range. One dog was euthanized after developing abdominal ascites and pleural effusion of unknown etiology after 450 days of APOQUEL administration. During the study, dogs could not be treated with other drugs that could affect the assessment of effectiveness, such as corticosteroids, anti-histamines, or cyclosporine. Bone marrow hyperplasia was consistent with response to sepsis. ACVM No. The dosage will depends on your dog’s weight. Two dogs each developed a Grade II mast cell tumor after 52 and 91 days of APOQUEL administration, respectively. Federal (USA) Law restricts this drug to use by or on the order of a licensed veterinarian. A margin of safety study in 6-month-old dogs was discontinued after four months due to the development of bacterial pneumonia and generalized demodex mange infections in dogs in the high dose (3X and 5X) treatment groups, dosed at 1.8 and 3.0 mg/kg oclacitinib twice daily, for the entire study. Following IV and PO administration, the terminal t1/2 appeared similar with mean values of 3.5 (2.2, 4.7) and 4.1 (3.1, 5.2) hours, respectively. By Day 30, 86% (127/147) of the placebo group dogs and 15% (23/152) of the APOQUEL group dogs withdrew from the masked study because of worsening clinical signs, and had the option to enroll in an unmasked study and receive APOQUEL. The chemical composition of APOQUEL is N-methyl[trans-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino) cyclohexyl]methanesulfonamide (2Z)-2-butenedioate. Dogs on APOQUEL had decreased leukocytes (neutrophil, eosinophil, and monocyte counts) and serum globulin, and increased cholesterol and lipase compared to the placebo group but group means remained within the normal range. Dogs were randomized to treatment with APOQUEL (152 dogs: tablets administered at a dose of 0.4-0.6 mg/kg per dose twice daily for 14 days and then once daily) or placebo (147 dogs: vehicle control, tablets administered on the same schedule). Dosage and administration Administer Canine Atopic Dermatitis lmmunotherapeutic* by subcutaneous injection at a minimum dose of 0.9 mg/ lb body weight according to the dosing table. The dose is 0.18 to 0.27 mg/lb of body weight, meaning the recommended initial dosage for a dog weighing 6.6 to 9.9 pounds is one half of a 3.6 mg tablet twice per day, for example. Tel: 0800 963 847; www.zoetis.co.nz. During the 30-day study, there were no fatalities and no adverse reactions requiring hospital care. The product does not contain a preservative. Apoquel Dosing Chart . Apoquel is not FDA approved to use twice daily longer than 14 days. APOQUEL may be administered with or without food. APOQUEL safety speaks volumes. flea allergic dermatitis, contact dermatitis, food hypersensitivity). APOQUEL tablets may be administered with or without food. Only the 20 mg and 60 mg tablets of GALLIPRANT are scored. During the study, dogs could not be treated with other drugs that could affect the assessment of pruritus or dermal inflammation such as corticosteroids, anti-histamines, or cyclosporine. Note: Never give this medicine to your dog without the approval of your vet, and always follow the exact recommendations of your vet. Serum cholesterol increased in 25% of APOQUEL group dogs, but mean cholesterol remained within the reference range. The chemical structure of oclacitinib maleate is: Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. For modified live canine parainfluenza virus (CPI), < 80% (6 of 8) of the dogs achieved adequate serologic response. Mean lymphocyte count for dogs in the APOQUEL group increased at Day 7, but returned to pretreatment levels by study end without a break in APOQUEL administration. Dosage and Administration. When treating pruritus associated with allergic dermatitis with oclacitinib, investigate and treat any underlying causes (e.g. Oclacitinib is not a corticosteroid or an antihistamine. So, there had to be side effects. Hemangiosarcoma is Blood or Skin Cancer in Dogs and Cats. For use in dogs only. Adverse reactions reported (and percent of dogs affected) during Days 0-16 included diarrhea (4.6% APOQUEL, 3.4% placebo), vomiting (3.9% APOQUEL, 4.1% placebo), anorexia (2.6% APOQUEL, 0% placebo), new cutaneous or subcutaneous lump (2.6% APOQUEL, 2.7% placebo), and lethargy (2.0% APOQUEL, 1.4% placebo). The following dosage should be viewed as a general guideline only. After completing APOQUEL field studies, 239 dogs enrolled in an unmasked (no placebo control), continuation therapy study receiving APOQUEL for an unrestricted period of time. Microscopic findings considered to be oclacitinib maleate-related included decreased cellularity (lymphoid) in Gut-Associated Lymphoid Tissue (GALT), spleen, thymus, cervical and mesenteric lymph node; and decreased cellularity of sternal and femoral bone marrow. The use of APOQUEL has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Apoquel dosing provides 3.6 mg, 5.4 mg, or 16 mg of oclacitinib per tablet, and each manufactured bottle is packaged with 20 counts or 100 counts of scored tablets. Between the masked and unmasked study, 283 dogs received at least one dose of APOQUEL. In dogs, oclacitinib maleate is rapidly and well absorbed following oral administration, with mean time to peak plasma concentrations (Tmax) of less than 1 hour. Oclacitinib has low protein binding with 66.3-69.7% bound in fortified canine plasma at nominal concentrations ranging from 10-1000 ng/mL. Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis, and neoplasia. Dosage and Administration The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. (3.6 kgs) cannot be accurately dosed. The dose of Apoquel is 0.18 to 0.27mg depending on the bodyweight of your dog. One dog developed a moderately severe bronchopneumonia after 272 days of APOQUEL administration; this infection resolved with antimicrobial treatment and temporary discontinuation of APOQUEL. Two other dogs on APOQUEL were withdrawn from study due to suspected or confirmed malignant neoplasia and subsequently euthanized, including one dog that developed signs associated with a heart base mass after 21 days of APOQUEL administration, and one dog that developed a Grade III mast cell tumor after 60 days of APOQUEL administration. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Apoquel requires a prescription from your veterinarian. The antipruritic effects of the Apoquel wear off quickly, within 12-24 hours, so the medication needs to be given daily in most cases. Available for Android and iOS devices. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing. Can be used long-term for maintenance therapy or short-term 4,5; Can be used with many other medications 4: . Shop WalmartPetRx.com for Apoquel Tablet and all of your other pet medications. The duration of sedation increased with the dosage level. Clinical observations that were considered likely to be related to oclacitinib maleate included papillomas and a dose-dependent increase in the number and frequency of interdigital furunculosis (cysts) on one or more feet during the study. Heartworm Preventive Comparison Chart for Dogs and Cats. Apoquel Dosing Chart. Compared to the placebo group, mean Owner-assessed pruritus VAS scores (on Days 1, 2, 7, 14, and 28) and Veterinarian-assessed CADESI scores (on Days 14 and 28) were lower (improved) in dogs in the APOQUEL group. The dosage should be calculated in half tablet increments. Back to. Heartworm Treatment for Dogs. In most of these cases, signs spontaneously resolved with continued dosing. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. APOQUEL … Each strength tablets are packaged in 100 and 250 count bottles. The data sheet provided by Zoetis gives the following doses: If your Labrador weighs… 45 – 59.9lb, a single dose is two 5.4mg tablets; 60 – 89.9lb, a single dose is one 16mg tablet APOQUEL (oclacitinib maleate) is a synthetic Janus Kinase (JAK) inhibitor. Eight dogs received placebo (empty gelatin capsule) at the same dosage schedule. A double-masked, 112-day, controlled study was conducted at 18 U.S. veterinary hospitals. While pet parents search for the root of the cause, Apoquel’s safe and effective treatment helps take the itch away so dogs can get back to their daily duties. Treatment of trazodone overdose generally consists of symptomatic and supportive care. The large dosing syringe fits onto the bottle and has dosing marks in 5-lb increments (up to 160 lbs), designed to deliver the daily maintenance dose of 0.045 mg/lb (0.1 mg/kg). Of these 239 dogs, one dog developed demodicosis following 273 days of APOQUEL administration. Based on that, A dog of 6.6 to 9 … In case of accidental ingestion, seek medical attention immediately. Dexmedetomidine-induced sedation occurred on each dosing day at all dose levels from 2 to 8 hours post-dosing. Control of Pruritus Associated with Allergic Dermatitis. Each tablet is scored and marked with AQ and either an S, M, or L that correspond to the different tablet strengths on both sides. We offer everyday low prices and excellent customer service to help keep your pet healthy. Clinical observations that were considered likely to be related to oclacitinib maleate treatment included enlarged lymph nodes, interdigital furunculosis, cysts, and pododermatitis. Äc¾ÿ*Í(eÄùqžÂu~ƒkԊNHÕy§ZJ{ ˜é“d¾Â”FâÑP¯B1´Aä(ÉzÝ~ôGNžø֍]ëXXêl­O,úþËW÷Ë?ô~þ£{֎0þ` j…ò# Treatment success for each dog was defined as at least a 2 cm decrease from baseline on a 10 cm visual analog scale (VAS) in pruritus, assessed by the Owner, on at least 5 of the 7 evaluation days. You lab’s weight will determine the starting dose of Apoquel. After one week of treatment, 86.4% of APOQUEL group dogs compared with 42.5% of placebo group dogs had achieved a 2 cm reduction on the 10 cm Owner-assessed pruritus VAS. Indicated for the treatment of pruritus associated with allergic dermatitis and the clinical manifestations of atopic dermatitis in dogs. Repeat administration monthly, as needed. Mean time on this study was 372 days (range 1 to 610 days). For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. Dogs receiving Apoquel tablets should therefore be monitored periodically with complete blood counts and serum biochemistry when on long-term treatment. Please wait a moment while we find what you are looking for… CYTOPOINT ® provides long-lasting itch relief for dogs with allergic or atopic dermatitis. Hemivertebrae are Congenitally Deformed Vertebra in Dogs and Cats. For dogs that continued APOQUEL treatment beyond one month, the mean Owner-assessed pruritus VAS scores and Veterinarian-assessed CADESI scores continued to improve through study end at Day 112. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 – 0.27 mg/lb. Oclacitinib maleate was administered to healthy, one-year-old Beagle dogs twice daily for 6 weeks, followed by once daily for 20 weeks, at 0.6 mg/kg (1X maximum exposure dose, 8 dogs), 1.8 mg/kg (3X, 8 dogs), and 3.0 mg/kg (5X, 8 dogs) oclacitinib for 26 weeks. DOGS 540 lb 2.318.1 kg Draw full volume from ONE 1-mL vial as indicated. Administer Cytopoint™ at a minimum dose of 0.9 mg/lb (2 mg/kg) body weight. Fax: 877-701-2220. One dog developed dermal pigmented viral plaques following 266 days of APOQUEL administration. Norman weighs roughly 20 pounds, so he takes a 5.4mg pill. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Of these 283 dogs, two dogs were withdrawn from study due to suspected treatment-related adverse reactions: one dog that had an intense flare-up of dermatitis and severe secondary pyoderma after 19 days of APOQUEL administration, and one dog that developed generalized demodicosis after 28 days of APOQUEL administration. The study enrolled 436 client-owned dogs with a history of allergic dermatitis attributed to one or more of the following conditions: atopic dermatitis, flea allergy, food allergy, contact allergy, and other/unspecified allergic dermatitis. Beranda › apoquel dosing chart › apoquel dosing chart canada › apoquel dosing chart dogs › apoquel dosing chart kg › apoquel dosing chart noah. Every effort has been made to ensure the accuracy of the Apoquel information published above. Apoquel Atopic Dermatitis Oclacitinib Tablet Treatment For Dogs In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. DOGS <5 lb <2.3 kg 0.09 mL/lb (0.2 mL/kg) drawn from ONE 10-mg vial. When using the large syringe, the dog’s weight should be rounded down to the nearest 5-lb increment. Apoquel is sold per tablet or 100 count bottle in three strengths; Apoquel 3.6 mg tablet, Apoquel 5.4 mg tablet, and Apoquel 16 mg tablet. On each of the 7 days, mean Owner-assessed pruritus VAS scores were lower in dogs in the APOQUEL group (See Figure 1). Five APOQUEL group dogs were withdrawn from study because of: darkening areas of skin and fur (1 dog); diarrhea (1 dog); fever, lethargy and cystitis (1 dog); an inflamed footpad and vomiting (1 dog); and diarrhea, vomiting, and lethargy (1 dog). Oclacitinib is metabolized in the dog to multiple metabolites and one major oxidative metabolite was identified in plasma and urine. hÞ|P]‹ƒ0ü+ûLbªQ(ÂÕ;}’õ᠔âÙåðh‰)xÿþò¡¯>„™$3;»›…㑼)}’Ë™ìጠcÀÓ8H¢9Ýo{‚\>5>õ|fÜl€. Necropsy revealed pneumonia of short duration and evidence of chronic lymphadenitis of mesenteric lymph nodes. Wash hands immediately after handling the tablets. Dosage and Administration The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Of course, to many dog owners, the side effects of Apoquel might be alarming but at the end of the day, you should remember that it is a chemical created by us to help relieve our dogs. Glucocorticoids are very effective in treating the signs of atopic dermatitis. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. Keep this and all drugs out of reach of children. However, this is only applicable for the first 14 days. How is Apoquel Available? Apoquel is for use in dogs over 12 months in age and weighing more than 6.6 lbs. With that, you will be able to give them the right dosage. Apoquel dosage for dogs with allergic dermatitis. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. APOQUEL is safe to use in dogs 12 months of age or older. One of the 147 dogs in the placebo group developed a Grade I mast cell tumor and was withdrawn from the masked study. This product is not for human use. Helicobacter Infection in Dogs and Cats. Heartworm: The Parasite. APOQUEL is not for use in dogs less than 12 months of age (see Animal Safety). Apoquel dosage in dogs. 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